Brian DeHaven, Ph.D.
Dr. DeHaven’s lab focuses on viruses and the immune responses our bodies have evolved to fight them. Specifically, he is interested in ectromelia, the virus that causes mousepox, which is a close relative to smallpox. Many viruses encode for genes that disrupt the ability of the host to mount an immune response; we use mousepox as a model for more deadly human viruses. By studying these genes, we can learn about the ways that viruses infect our cells, but also how the immune system recognizes and responds to infection.
Before coming to La Salle, Dr. DeHaven was a visiting professor of microbiology at Haverford College and a postdoctoral fellow in the Eisenlohr lab at Thomas Jefferson University in Philadelphia. He holds a PhD from the Isaacs lab at the University of Pennsylvania and a bachelor’s degree from the University of Michigan.
Areas of Expertise
- PhD in Microbiology, Perelman School of Medicine, University of Pennsylvania, 2011
- BS in Biology, University of Michigan (2005)
- Biology 210- Cell Biology and Genetics
- Biology 303- Microbiology
- 47X special topics- Virology (even years), Immunology (odd years)
Epithelial immunization induces polyfunctional CD8+ T cells optimal mousepox protection. Hersperger AR, Siciliano NA, DeHaven BC, Snook AE, Eisenlohr LC. J Virol. 2014 Aug 15;88(16):9472-5. doi: 10.1128/JVI.01464-14. Epub 2014 Jun 4.
DeHaven BC, Gupta K, Isaacs SN. The vaccinia virus A56 protein: A multi- functional transmembrane glycoprotein that anchors two secreted viral proteins. J Gen Virol. 2011 Sep;92(Pt 9):1971-80. Epub 2011 Jun 29. Review.
DeHaven BC, Girgis NM, Xiao Y, Hudson PN, Olson VA, Damon IK, Isaacs SN. Poxvirus complement control proteins are expressed on the cell surface through an intermolecular disulfide bridge with the viral A56 protein. J Virol. 2010 Nov;84(21):11245-54. Epub 2010 Aug 18.
Girgis NM, DeHaven BC, Xiao Y, Isaacs SN. The vaccinia virus complement control protein modulates adaptive immune responses during infection. J Virol. 2011 Mar;85(6):2547-56. Epub 2010 Dec 29.
Girgis NM, DeHaven BC, Fan X, Viner KM, Shamim M, Isaacs SN. Cell surface expression of the vaccinia virus complement control protein is mediated by interaction with the viral A56 protein and protects infected cells from complement attack. J Virol. 2008 May;82(9):4205-14.